5-Chloroindole-2-carboxylic acid methyl ester

CAS: 87802-11-7

Ref. 3D-FC56771

Product Information

• Name: 5-Chloroindole-2-carboxylic acid methyl ester
• Synonyms: 5-Chloro-1H-indole-2-carboxylic acid methyl esterMethyl 5-chloroindole-2-carboxylate
• Brand: Biosynth
• Description: 5-Chloroindole-2-carboxylic acid methyl ester is a potent inhibitor of the enzyme tyrosine kinase in cell culture, with an IC50 value of 0.5 nM. It has been shown to inhibit the growth of cancer cells (e.g., MDA-MB231, MCF-7) in vitro and in vivo. The IC50 values for inhibition of MDA-MB231 and MCF-7 cells are 0.1 and 10 nM, respectively. 5-Chloroindole-2-carboxylic acid methyl ester binds to the ATP binding site on tyrosine kinase, preventing ATP from binding and inhibiting phosphorylation of the receptor protein. This allows the receptor's downstream signaling pathways to be blocked, which leads to cell growth inhibition by arresting cell cycle progression at G0/G1 phase or inducing apoptosis.

Chemical properties

• Molecular weight: 209.63 g/mol
• Formula: C₁₀H₈ClNO₂
• Purity: Min. 95%