Product Information
- 1,3-Diisopropylcarbodiimide N,N'-Diisopropylcarbodiimide
- (E)-dipropan-2-yldiazene
- (Propan-2-yl)([[(propan-2-yl)imino]methylidene])amine
- 1,3-Diisopropylcarbodiimide
- 2-Propanamine, N,N'-methanetetraylbis-
- Carbodiimide, diisopropyl-
- Carbodimide, N,N'-Diisopropyl-
- Diisopropyl-Carbodiimid
- Diisopropylcarbodiimide
- Dipc
- See more synonyms
- Dipcdi
- Dipci
- N,N'-Diisopropyl carbodiimide
- N,N'-Methanetetraylbis(1-methylethylamine)
- N,N'-Methanetetraylbis(2-propanamine)
- N,N'-Methantetraylbis(1-methylethylamin)
- N,N'-dipropan-2-ylcarbodiimide
- N,N'-metanotetrailbis(1-metiletilamina)
- N,N′-Diisopropylmethanediimine
- Nsc 42080
- PCI
- N,N′-Diisopropylcarbodiimide
DIC is a carbodiimide used as a coupling reagent for amide and ester formation, widely employed in peptide synthesis in presence of additives such as HOBt or HOAt to supress racemisation. Being a liquid, DIC is easier to handle than the solid DCC and forms a DCM-soluble urea by-product, while DCC generates a urea by-product insoluble in most organic solvents. Since the presence of insoluble urea is reportedly problematic in solid-phase peptide synthesis, for this application DIC is more suitable than DCC. A possible side-reaction with DIC and carbodiimides in general is the formation of an N-acylurea, which can be limited by conducting the reaction in DCM or chloroform at low temperatures, and by adding the amine at last.
Chemical properties
Technical inquiry about: 3D-FD02073 DIC
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