CAS 693-13-0

Diisopropylcarbodiimide

Description:

Diisopropylcarbodiimide (DIC) is an organic compound characterized by its carbodiimide functional group, which features a central carbon atom double-bonded to two nitrogen atoms and single-bonded to two isopropyl groups. It is a colorless to pale yellow liquid with a distinctive odor and is known for its role as a coupling agent in peptide synthesis and other organic reactions. DIC is highly reactive, particularly with carboxylic acids, facilitating the formation of amides and esters through the activation of these acids. It is soluble in organic solvents such as dichloromethane and acetonitrile but is less soluble in water. Due to its reactivity, DIC can form stable intermediates, making it valuable in various synthetic applications. However, it should be handled with care, as it can be irritating to the skin, eyes, and respiratory system. Proper safety precautions, including the use of personal protective equipment, are essential when working with this compound in laboratory settings.

Formula: C₇H₁₄N₂

InChI: InChI=1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3

InChI key: InChIKey=BDNKZNFMNDZQMI-UHFFFAOYSA-N

SMILES: C(=NC(C)C)=NC(C)C

Synonyms:

• (E)-dipropan-2-yldiazene
• (Propan-2-yl)([[(propan-2-yl)imino]methylidene])amine
• 1,3-Diisopropylcarbodiimide
• 2-Propanamine, N,N'-methanetetraylbis-
• Carbodiimide, diisopropyl-
• Carbodimide, N,N'-Diisopropyl-
• DIC
• Diisopropyl-Carbodiimid
• Diisopropylcarbodiimide
• Dipc
• Dipcdi
• Dipci
• N,N'-Diisopropyl carbodiimide
• N,N'-Methanetetraylbis(1-methylethylamine)
• N,N'-Methanetetraylbis(2-propanamine)
• N,N'-Methantetraylbis(1-methylethylamin)
• N,N'-dipropan-2-ylcarbodiimide
• N,N'-metanotetrailbis(1-metiletilamina)
• N,N′-Diisopropylmethanediimine
• Nsc 42080
• PCI

N,N'-Diisopropylcarbodiimide

CAS: 693-13-0

Formula: C₇H₁₄N₂

Purity: >98.0%(GC)

Color and Shape: Colorless to Almost colorless clear liquid

Molecular weight: 126.20

Ref: 3B-D0254

N,N'-Diisopropylcarbodiimide, 99%

CAS: 693-13-0

N,N'-Diisopropylcarbodiimide is used as a reagent in synthetic organic chemistry. It serves as a chemical intermediate and as a stabilizer for Sarin (chemical weapon). It is also used in the synthesis of peptide and nucleic acid. Further, it is used as an antineoplastic and involved in the treatment

Formula: C₇H₁₄N₂

Purity: 99%

Color and Shape: Liquid, Clear colorless to yellow

Molecular weight: 126.20

Ref: 02-A19292

(propan-2-yl)({[(propan-2-yl)imino]methylidene})amine

CAS: 693-13-0

Formula: C₇H₁₄N₂

Purity: 98%

Color and Shape: Liquid

Molecular weight: 126.1995

Ref: IN-DA0035B8

N,N''-Diisopropylcarbodiimide

CAS: 693-13-0

Formula: C₇H₁₄N₂

Purity: ≥ 98.5%

Color and Shape: Clear, colourless to light-yellow liquid

Molecular weight: 126.20

Ref: 7W-GM2363

N,N'-Bis(isopropyl)carbodiimide

CAS: 693-13-0

N,N'-Bis(isopropyl)carbodiimide

Formula: C₇H₁₄N₂

Purity: 99%

Color and Shape: Clear, colourless to slightly yellow. Liquid-Clear

Molecular weight: 126.19946

Ref: 54-OR18304

N,N'-Diisopropylcarbodiimide

Controlled Product

CAS: 693-13-0

Applications N,N'-Diisopropylcarbodiimide can be used as an alternative to N,N’-Dicyclohexylcarbodiimide (D438500) in peptide synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996); Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000); Collingwood, S.P., et al.: Tetrahedron Lett. 28, 4445, (1987); Benoiton, N.L., et al.: J. Chem. Soc., Chem. Commun., 543, (1981)

Formula: C₇H₁₄N₂

Color and Shape: Neat

Molecular weight: 126.2

Ref: TR-D455495

DIC

CAS: 693-13-0

DIC is a carbodiimide used as a coupling reagent for amide and ester formation, widely employed in peptide synthesis in presence of additives such as HOBt or HOAt to supress racemisation. Being a liquid, DIC is easier to handle than the solid DCC and forms a DCM-soluble urea by-product, while DCC generates a urea by-product insoluble in most organic solvents. Since the presence of insoluble urea is reportedly problematic in solid-phase peptide synthesis, for this application DIC is more suitable than DCC. A possible side-reaction with DIC and carbodiimides in general is the formation of an N-acylurea, which can be limited by conducting the reaction in DCM or chloroform at low temperatures, and by adding the amine at last.

Formula: C₇H₁₄N₂

Purity: Min. 99.0%

Color and Shape: Colorless Clear Liquid

Molecular weight: 126.2 g/mol

Ref: 3D-FD02073

N,N'-Diisopropylcarbodiimide

CAS: 693-13-0

Formula: (CH₃)₂CHNCNCH(CH₃)₂

Color and Shape: colorless to light yellow liq.

Molecular weight: 126.2

Ref: 08-07-0190

1,3-Diisopropylcarbodiimide

CAS: 693-13-0

Please enquire for more information about 1,3-Diisopropylcarbodiimide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₇H₁₄N₂

Purity: Min. 99.0%

Molecular weight: 126.20 g/mol

Ref: 3D-J-670017

N,N-Diisopropyl Carbodiimide (DIPC) extrapure, 99%

CAS: 693-13-0

Formula: C₇H₁₄N₂

Purity: min. 99%

Color and Shape: Clear, Colourless to pale yellow to yellow, Liquid

Molecular weight: 126.20

Ref: SR-43913