Product Information
Name:DIC
Synonyms:
- 1,3-Diisopropylcarbodiimide N,N'-Diisopropylcarbodiimide
Brand:Biosynth
Description:DIC is a carbodiimide used as a coupling reagent for amide and ester formation, widely employed in peptide synthesis in presence of additives such as HOBt or HOAt to supress racemisation. Being a liquid, DIC is easier to handle than the solid DCC and forms a DCM-soluble urea by-product, while DCC generates a urea by-product insoluble in most organic solvents. Since the presence of insoluble urea is reportedly problematic in solid-phase peptide synthesis, for this application DIC is more suitable than DCC. A possible side-reaction with DIC and carbodiimides in general is the formation of an N-acylurea, which can be limited by conducting the reaction in DCM or chloroform at low temperatures, and by adding the amine at last.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:126.2 g/mol
Formula:C7H14N2
Purity:Min. 99.0%
Color/Form:Colorless Clear Liquid
InChI:InChI=1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3
InChI key:InChIKey=BDNKZNFMNDZQMI-UHFFFAOYSA-N
SMILES:CC(C)N=C=NC(C)C
Technical inquiry about: DIC
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