Dihydrocyclosporin A

CAS: 59865-15-5

Ref. 3D-FD21913

Product Information

• Name: Dihydrocyclosporin A
• Synonyms: 6-[(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)octanoic acid]cyclosporin A
• Brand: Biosynth
• Description: Dihydrocyclosporin A is an immunosuppressant, which is a cyclic undecapeptide derived from fungal metabolites, specifically from the soil fungus Tolypocladium inflatum. This compound functions through the inhibition of calcineurin, which is a crucial phosphatase involved in the activation of T-cells. By binding to the intracellular protein cyclophilin, Dihydrocyclosporin A forms a complex that inhibits calcineurin activity, subsequently blocking the transcription of interleukin-2 and other cytokines essential for T-cell proliferation.

Chemical properties

• Molecular weight: 1,204.63 g/mol
• Formula: C₆₂H₁₁₃N₁₁O₁₂
• Purity: Min. 95 Area-%
• Color/Form: Powder