4,6-Dichloroindole-2-carboxylic acid

CAS: 101861-63-6

Ref. 3D-FD33803

Product Information

• Name: 4,6-Dichloroindole-2-carboxylic acid
• Synonyms: 4,6-Dichloroindole-2-Carboxylic Acid, 4,6-Dicloroindole-2-carboxylic acid, 4,6-Dicloroindole-2-Carboxylic, 4,6-Dichloroindole-2-carboxylic

Description

4,6-Dichloroindole-2-carboxylic acid (DCI) is a potential drug candidate for the treatment of neurological disorders. DCI binds to glutamate receptors, which are involved in many neurological diseases. It has been shown to inhibit glutamate dehydrogenase and thus block the production of glutamate from glucose. DCI also prevents neuronal death caused by excessive levels of glutamate and inhibits the activation of N-methyl-D-aspartate (NMDA) receptors. This drug is currently being investigated as a therapy for inflammatory diseases such as multiple sclerosis and Alzheimer's disease. One study has shown that DCI may be useful for treating cerebellar granule cells in a model system. It has been found to inhibit glycogen synthase kinase 3, which is an enzyme involved in signaling pathways that regulate cell growth and survival.

• Brand: Biosynth

Chemical properties

• Molecular weight: 230.05 g/mol
• Formula: C₉H₅Cl₂NO₂
• Purity: Min. 95%
• Color/Form: White Powder
• InChI: InChI=1S/C9H5Cl2NO2/c10-4-1-6(11)5-3-8(9(13)14)12-7(5)2-4/h1-3,12H,(H,13,14)
• InChI key: InChIKey=DHXISZKSSIWRLH-UHFFFAOYSA-N
• SMILES: O=C(O)c1cc2c(Cl)cc(Cl)cc2[nH]1