Elesclomol

CAS: 488832-69-5

Ref. 3D-FE157996

Product Information

• Name: Elesclomol
• Synonyms: 1, 3-Bis[2-methyl-2-(phenylthioxomethyl)hydrazide]propanedioic acid, 1,3-Bis[2-methyl-2-(phenylthioxomethyl)hydrazide]propanedioic acid, 1-N′,3-N′-Bis(benzenecarbonothioyl)-1-N′,3-N′-dimethylpropanedihydrazide, Gsk 842879A, N'~1~,N'~3~-dimethyl-N'~1~,N'~3~-bis(phenylcarbothioyl)propanedihydrazide, NSC 174939, Propanedioic acid, 1,3-bis[2-methyl-2-(phenylthioxomethyl)hydrazide], Propanedioic acid, bis[2-methyl-2-(phenylthioxomethyl)hydrazide], Sta 4783

Description

Elesclomol is a novel matrix metalloproteinase inhibitor that has been shown to inhibit the growth of cancer cells. It binds to the active site of matrix metalloproteinases-9 and -2, which are enzymes that degrade the extracellular matrix, thus preventing invasion and metastasis. Elesclomol also inhibits mitochondrial functions by decreasing ATP production, leading to cell death. It has been shown to inhibit the activity of DNA polymerase in HL60 cells, a human myeloid leukemia cell line. This drug also blocks the response element for hypoxia-inducible factor 1 alpha (HIF-1α), an important transcription factor involved in cellular response to hypoxia, leading to decreased expression of genes required for energy metabolism and mitochondrial functions. Elesclomol also inhibits caspase-independent cell death induced by pharmacological agents such as carboplatin. The binding site on elesclomol is hydrophobic and

• Brand: Biosynth

Chemical properties

• Molecular weight: 400.52 g/mol
• Formula: C₁₉H₂₀N₄O₂S₂
• Purity: Min. 95%
• Color/Form: Powder