Fmoc-Trp(Me)-OH

CAS: 1334509-86-2

Ref. 3D-FF111359

Product Information

• Name: Fmoc-Trp(Me)-OH
• Synonyms: Fmoc-Trp(1-Me)-OH, Fmoc-L-Trp(Me)-OH

Description

Fmoc-Trp(Me)-OH is a peptide that has been synthesized as an inhibitor of the enzyme cytochrome P450, which is involved in the metabolism of drugs. Fmoc-Trp(Me)-OH inhibits the activity of cytochrome P450 by binding to its active site and preventing access to substrates. The affinity and conformation of Fmoc-Trp(Me)-OH are optimized for optimal inhibition of cytochrome P450. Half-life values have been determined from a study using rats, which showed that Fmoc-Trp(Me)-OH had a half life of about 8 hours. Hydrophobic interactions between Fmoc-Trp(Me)-OH and the active site of cytochrome P450 are responsible for its inhibitory potency.

• Brand: Biosynth

Chemical properties

• Molecular weight: 440.49 g/mol
• Formula: C₂₇H₂₄N₂O₄
• Purity: Min. 95%
• Color/Form: Off-White Powder
• InChI: InChI=1S/C27H24N2O4/c1-29-15-17(18-8-6-7-13-25(18)29)14-24(26(30)31)28-27(32)33-16-23-21-11-4-2-9-19(21)20-10-3-5-12-22(20)23/h2-13,15,23-24H,14,16H2,1H3,(H,28,32)(H,30,31)/t24-/m0/s1
• InChI key: InChIKey=GDPXIUSEXJJUGT-DEOSSOPVSA-N
• SMILES: Cn1cc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)c2ccccc21