Folinic acid

CAS: 58-05-9

Ref. 3D-FF156776

Product Information

• Name: Folinic acid
• Synonyms: Leucovorin, (6R,S)-5-Formyltetrahydrofolate, 10-Formyl-7,8-dihydrofolic acid, 5-Formyl-5,6,7,8-tetrahydrofolic acid, 5-Formyltetrahydrofolic Acid, 5-Formyltetrahydrofolsaure, 5-Formyltetrahydropteroylglutamic acid, <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, Acide 5-Formyltetrahydrofolique, Acido 5-Formiltetrahidrofolico, CF, Folinic acid-SF, Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, <span class="text-smallcaps">L</span>-, Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, L-, Kunyrin, L-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, Leucal, Leucoverin, Levoleucovorin, N-[4-[[(2-Amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid, N5-Formyl-5,6,7,8-tetrahydrofolic acid, N5-Formyltetrahydrofolic acid, N⁵-Formyl-5,6,7,8-tetrahydrofolic acid, N⁵-Formyl-THF, N⁵-Formyltetrahydrofolic acid, Welcovorin, l-Leucovorin

Description

Folinic acid is a vitamin-B9 that is used as a cofactor for enzymes involved in the synthesis of DNA and RNA. It is also used to diagnose various infectious diseases, with high values found in patients with cancer or autoimmune diseases. Folinic acid has been shown to have dose-dependent effects on mammalian cells, exhibiting toxicities at higher concentrations. Folinic acid can be used to repair damaged DNA by acting as a glycosidase that breaks down the glycosidic bond between the base and sugar.

• Brand: Biosynth

Chemical properties

• Molecular weight: 473.44 g/mol
• Formula: C₂₀H₂₃N₇O₇
• Purity: Min. 97%
• Color/Form: White Powder
• InChI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12?,13-/m0/s1
• InChI key: InChIKey=VVIAGPKUTFNRDU-ABLWVSNPSA-N
• SMILES: Nc1nc2c(c(=O)[nH]1)N(C=O)C(CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1)CN2