Homoharringtonine

CAS: 26833-87-4

Ref. 3D-FH15974

Product Information

• Name: Homoharringtonine
• Synonyms: Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
• Brand: Biosynth
• Description: Homoharringtonine is an alkaloid isolated as an anticancer agent, which is derived from the Cephalotaxus genus of evergreen trees and shrubs. It is specifically extracted from the leaves and bark, traditionally known for its therapeutic applications in Chinese medicine. The mode of action of Homoharringtonine involves the inhibition of protein synthesis. It achieves this by binding to the A-site of the ribosomal subunit, impeding the elongation phase of protein synthesis and thus disrupting cellular proliferation.

Chemical properties

• Molecular weight: 545.62 g/mol
• Formula: C₂₉H₃₉NO₉
• Purity: Min. 98 Area-%
• Color/Form: White Powder
• InChI: InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1
• InChI key: InChIKey=HYFHYPWGAURHIV-JFIAXGOJSA-N
• SMILES: COC(=O)C[C@](O)(CCCC(C)(C)O)C(=O)O[C@@H]1C(OC)=C[C@]23CCCN2CCc2cc4c(cc2[C@H]13)OCO4