Product Information
- 2-[4-[(dimethylamino)methyl]phenyl]-5,6-dihydro-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one
AG 14361 is a potent and selective inhibitor of the methyltransferase enzyme, which is involved in the synthesis of methionine from homocysteine. AG 14361 has been shown to reduce tumor growth in mouse models of cancer by inhibiting the expression of basic proteins that are involved in wound repair. This compound also has pharmacokinetic properties that are not affected by radiation therapy or chemotherapy. Additionally, AG 14361 has cytotoxic effects on cells, causing cell lysis and neuronal death. In vitro assays have shown that AG 14362 inhibits DNA binding and enzymatic activities of methionine synthase, protein methyltransferase (PMT), and DNA-dependent RNA polymerase II. It also inhibits the activity of enzyme methylenetetrahydrofolate reductase (MTHFR). These findings support the use of this inhibitor as a potential chemotherapeutic agent for human cancers.
Chemical properties
Technical inquiry about: 3D-FI43360 AG 14361
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