Phentolamine methanesulfonate

CAS: 65-28-1

Ref. 3D-FP26896

Product Information

• Name: Phentolamine methanesulfonate
• Synonyms: 2-[N-(m-Hydroxyphenyl)-p-toluidinomethyl]imidazoline, methanesulfonate
• Brand: Biosynth
• Description: Phentolamine is a synthetic mesylate that is used as an antihypertensive agent, and for the treatment of Raynaud's syndrome and pheochromocytoma. Phentolamine is also used to prevent frostbite and to treat various types of shock. Phentolamine blocks alpha-2-adrenergic receptors, thereby decreasing sympathetic nerve impulses to the heart, blood vessels, kidneys, and other organs. This drug also acts as a histamine antagonist by blocking H1-receptors on vascular smooth muscle cells. Phentolamine has been shown to have no significant effects on 5-hydroxytryptamine (5HT) release in vitro or in vivo.

Chemical properties

• Molecular weight: 377.46 g/mol
• Formula: C₁₈H₂₃N₃O₄S
• Purity: Min. 95%
• Color/Form: White Powder
• InChI: InChI=1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)
• InChI key: InChIKey=OGIYDFVHFQEFKQ-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)O.Cc1ccc(N(CC2=NCCN2)c2cccc(O)c2)cc1