2,6-Pyridinedicarboxylic acid dimethyl ester
CAS: 5453-67-8
Ref. 3D-FP44227
25g | 150.00 € | ||
50g | 238.00 € | ||
100g | 367.00 € | ||
250g | 454.00 € | ||
500g | 633.00 € |
Product Information
- 2,6-Bismethoxycarbonylpyridine
- 2,6-Dicarbomethoxypyridine
- 2,6-Dimethyl pyridine-2,6-dicarboxylate
- 2,6-Dipicolinic acid dimethyl ester
- 2,6-Pyridinedicarboxylic acid, 2,6-dimethyl ester
- Dimethyl pyridine-2,6-dicarboxylate
- Dipicolinic acid dimethyl ester
- NSC 18855
- Dimethyl 2,6-pyridinedicarboxylate
2,6-Pyridinedicarboxylic acid dimethyl ester is a drug that has shown anticancer activity in animal models. It binds to DNA, forming a ternary complex with the DNA and the enzyme topoisomerase I. The binding of this drug to the enzyme prevents it from breaking the DNA strands during replication, causing the cell to die. It has been shown that 2,6-pyridinedicarboxylic acid dimethyl ester can be used as a non-competitive inhibitor of topoisomerase I. Furthermore, it has been demonstrated that 2,6-pyridinedicarboxylic acid dimethyl ester is able to bind to human endometrial cancer cells with high affinity. Finally, 2,6-pyridinedicarboxylic acid dimethyl ester was found in x-ray crystal structures of complexes with hydrogen bonds and low activation enthalpy and entropy.
Chemical properties
Technical inquiry about: 3D-FP44227 2,6-Pyridinedicarboxylic acid dimethyl ester
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