Senecivernine

CAS: 72755-25-0

Ref. 3D-FS161633

Product Information

• Name: Senecivernine
• Synonyms: (4R,5R,6R,14aR,14bR)-3,4,5,6,9,11,13,14,14a,14b-Decahydro-6-hydroxy-4,5,6-trimethyl-3-methylene[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, (4R,5R,6R,14aR,14bR)-6-Hydroxy-4,5,6-trimethyl-3-methylene-3,4,5,6,9,11,13,14,14a,14b-decahydro[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 21-Norsenecionan-11,16-dione, 12-hydroxy-14-methyl-, (14α)-, [1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-4,5,6-trimethyl-3-methylene-, [4R-(4R*,5R*,6R*,14aR*,14bR*)]-, [1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-4,5,6-trimethyl-3-methylene-, (4R,5R,6R,14aR,14bR)-

Description

Senecivernine is a natural compound that may have anti-inflammatory and cytotoxic effects. Senecivernine is an n-oxide of retrorsine, which is a toxic alkaloid found in plants of the genus Senecio. It has been shown to inhibit TNF-related apoptosis-inducing ligand (TRAIL) and to induce matrix metalloproteinase activity in vitro. The toxicity of senecivernine has been studied in mice and rats, where it was found to cause dose-dependent inhibition of weight gain, liver enlargement, and death. Senecivernine also inhibits the growth of cancer cells in culture. Senecivernine has been shown to be effective against methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium perfringens, although is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycob

• Brand: Biosynth

Chemical properties

• Molecular weight: 335.39 g/mol
• Formula: C₁₈H₂₅NO₅
• Purity: Min. 95%
• Color/Form: Powder