Product Information
Name:SAG
Synonyms:
- 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiophene-2-carboxamide
Brand:Biosynth
Description:Smoothened agonist and activator of the Hedgehog signalling pathway with EC50 of 3 nM. SAG binds to the Smoothened heptahelical bundle and antagonises effects of the Smoothened antagonist cyclopamine. In previous studies, SAG activated neurogenesis and neuronal survival in cell and animal models as well as improved cell differentiation of human induced pluripotent cells into the neuronal lineage.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:490.06 g/mol
Formula:C28H28ClN3OS
Purity:Min. 95%
Color/Form:White Powder
InChI:InChI=1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3
InChI key:InChIKey=VFSUUTYAEQOIMW-UHFFFAOYSA-N
SMILES:CNC1CCC(N(Cc2cccc(-c3ccncc3)c2)C(=O)c2sc3ccccc3c2Cl)CC1
Technical inquiry about: SAG
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