Product Information
- 1(3H)-Isobenzofuranone,3-butylidene-4,5,6,7-tetrahydro-6,7-dihydroxy-, (3Z,6R,7R)-rel-
- 1(3H)-Isobenzofuranone,3-butylidene-4,5,6,7-tetrahydro-6,7-dihydroxy-, (3Z,6a,7b)-
- rel-(3Z,6R,7R)-3-Butylidene-4,5,6,7-tetrahydro-6,7-dihydroxy-1(3H)-isobenzofuranone
Senkyunolide I is a natural product that has been identified as the major active constituent of Rhizoma Gastrodiae. It exhibits potent anti-inflammatory and anti-tumor activities. Senkyunolide I inhibits the activity of the enzyme glutathione reductase (GSH-px) and prevents mitochondrial membrane potential collapse by inhibiting ATPase activity and increasing intracellular calcium concentration. This compound also inhibits P-glycoprotein (Pgp) and exerts an antioxidant effect on neuronal cells, leading to apoptosis in vitro. Senkyunolide I has shown to be a potent inhibitor of tumor cell growth in vivo, with no toxicity effects observed in mice or rats.
Chemical properties
Technical inquiry about: 3D-FS73834 Senkyunolide I
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