Vadadustat

CAS: 1000025-07-9

Ref. 3D-FV168206

Product Information

• Name: Vadadustat
• CAS: 1000025-07-9

Description

Vadadustat is a drug that is used to treat iron overload caused by chronic transfusions in patients with chronic kidney disease. It is a matrix metalloproteinase inhibitor that inhibits the activity of MMP-9, which degrades collagen and elastin in the blood vessels. Vadadustat has been shown to be effective in experimental models of renal disease and heart failure. This drug also has a low potential for hepatotoxicity, as it does not affect the concentration-time curve for iron concentration in the liver or picolinic acid excretion. Vadadustat binds to transferrin receptors and prevents iron from being released into the body.

• Brand: Biosynth

Chemical properties

• Molecular weight: 306.7 g/mol
• Formula: C₁₄H₁₁ClN₂O₄
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
• InChI key: InChIKey=JGRXMPYUTJLTKT-UHFFFAOYSA-N
• SMILES: O=C(O)CNC(=O)c1ncc(-c2cccc(Cl)c2)cc1O