XAV 939

CAS: 284028-89-3

Ref. 3D-FX28737

Product Information

• Name: XAV 939
• Synonyms: 1,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-oneNVP-XAV 939
• Brand: Biosynth
• Description: Inhibits tankyrase (TNKS1 and TNKS2 with IC50 values of 11 and 4 nM respectively), by binding to the catalytic poly-ADP-ribose polymerase (PARP) domain. This stabilizes cytoplasmic protein Axin, mediating β-catenin depletion and thereby suppresses Wnt signalling pathway. XAV 939 has anti-proliferative and pro-apoptotic effects on neuroblastoma and colorectal cancer cells.

Chemical properties

• Molecular weight: 312.31 g/mol
• Formula: C₁₄H₁₁F₃N₂OS
• Purity: Min. 95%
• InChI: InChI=1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
• InChI key: InChIKey=KLGQSVMIPOVQAX-UHFFFAOYSA-N
• SMILES: O=c1[nH]c(-c2ccc(C(F)(F)F)cc2)nc2c1CSCC2