6-[2,5-Bis(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-3-yl]-2(3H)-benzothiazolone

CAS: 2034181-36-5

Ref. 3D-JGD18136

Product Information

• Name: 6-[2,5-Bis(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-3-yl]-2(3H)-benzothiazolone
• Brand: Biosynth
• Description: 6-[2,5-Bis(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-3-yl]-2(3H)-benzothiazolone is a novel small molecule that has been shown to be a potent and selective activator of the protein kinase C (PKC) family. It binds to the PKC alpha isoform with an IC50 of 0.5 nM and displays low nanomolar activity against PKC beta and gamma isoforms. The activation of PKC alpha by 6-[2,5-bis(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-3-yl]-2(3H)-benzothiazolone leads to increased phosphorylation of proteins involved in cell signaling pathways, including G protein coupled receptors (GPCRs), tyrosine kinases and

Chemical properties

• Molecular weight: 404.3 g/mol
• Formula: C₁₅H₆F₆N₄OS
• Purity: Min. 95%