Product Information
TAS-116 is a cytosolic inhibitor that disrupts the chaperone function of Hsp90. TAS-116 has potent antitumor activity in mouse tumor models and significant cytotoxicity against human stromal tumours. This drug inhibits epidermal growth factor (EGF) receptor signaling, which may be due to its ability to inhibit the ATPase activity of Hsp90. TAS-116 also interacts with the ATPase domain of Hsp90 and binds to two amino acid residues on the surface of the ATPase domain, which are important for substrate binding. These interactions have been shown to be critical for TAS-116’s inhibition of EGF receptor signaling and potent antitumor activity.
Chemical properties
Technical inquiry about: 3D-KAC53336 TAS-116
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