Product Information
- 6-Amino-2-chloro-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)purine
Clofarabine is a nucleoside that is used as an antileukemia drug. It is a metal chelate, and its mechanism of action involves incorporation into the DNA chain, which prevents DNA elongation by inhibiting DNA methyltransferase. Clofarabine has minimal toxicity and side-effect profiles. This agent inhibits the proliferation of leukemia cells in vitro by interfering with the synthesis of RNA and DNA. Clofarabine has been shown to be effective against acute toxicities caused by nonsteroidal anti-inflammatory drugs in pediatric patients.
Chemical properties
Technical inquiry about: 3D-NA07154 Clofarabine
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