CAS 123318-82-1
:Clofarabine
Description:
Clofarabine is a synthetic nucleoside analog primarily used in the treatment of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). It is characterized by its structure, which includes a purine base and a sugar moiety, modified to enhance its efficacy and stability. Clofarabine exhibits antineoplastic properties by interfering with DNA synthesis and repair, ultimately leading to apoptosis in cancer cells. Its mechanism of action involves inhibition of DNA polymerase and ribonucleotide reductase, which are crucial for DNA replication and repair processes. The compound is typically administered intravenously and is known for its potential side effects, including myelosuppression, gastrointestinal disturbances, and infections due to immunosuppression. Clofarabine's pharmacokinetics indicate a relatively short half-life, necessitating careful dosing and monitoring during treatment. Overall, it represents a significant advancement in targeted cancer therapies, particularly for patients with relapsed or refractory leukemia.
Formula:C10H11ClFN5O3
InChI:InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1
InChI key:InChIKey=WDDPHFBMKLOVOX-AYQXTPAHSA-N
SMILES:NC1=C2C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3F)=NC(Cl)=N1
Synonyms:- 2-CHLORO-2'-ARABINOFLUORO-2'-DEOXYADENOSINE
- 9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-
- (2R,4R,5R)-5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
- 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
- 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amin
- 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine
- Clolar
- 2-Chloro-9-(2-Deoxy-2-Fluoro-β-D-Arabinofuranosyl)-9H-Purin-6-Amine
- 2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine
- CAFDA
- 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine
- Clofarabine
- 5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
- Clofarex
- (2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-4-fluoro-2-(hydroxymethyl)-tetrahydrofuran-3-ol
- See more synonyms
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Clofarabine
CAS:Formula:C10H11ClFN5O3Purity:>98.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:303.682-Chloro-2'-arabino-fluoro-2'-deoxyadenosine, 99+%
CAS:A purine nucleoside anti-metabolite. Toxic to nondividing lymphocytes and monocytesThis Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item coFormula:C10H11ClFN5O3Purity:99+%Molecular weight:303.68Clofarabine
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C10H11ClFN5O3Color and Shape:White Off-White PowderMolecular weight:303.05345Clofarabine System Suitability Mixture
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiColor and Shape:White SolidClofarabine
CAS:Clofarabine (Clofarex)m, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotideFormula:C10H11ClFN5O3Purity:99.94% - >99.99%Color and Shape:SolidMolecular weight:303.677Clofarabine, free base
CAS:Clofarabine, free baseFormula:C10H11ClFN5O3Purity:By hplc: 99.9% (Typical Value in Batch COA)Color and Shape:SolidMolecular weight:303.67744Clofarabine-13C-15N3
CAS:Formula:CC9H11ClFN215N3O3Color and Shape:White To Off-White SolidMolecular weight:307.652-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
CAS:Formula:C10H11ClFN5O3Purity:97%Color and Shape:SolidMolecular weight:303.6774Clofarabine
CAS:Applications Second generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gandhi, V., et al.: Clin. Cancer Res., 9, 6335 (2003), Kantarjian, H., et al.: Blood, 102, 2379 (2003), Faderl, S., et al.: Cancer, 103, 1985 (2005),Formula:C10H11ClFN5O3Color and Shape:NeatMolecular weight:303.68Clofarabine
CAS:(2R,3R,4S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-olFormula:C10H11ClFN5O3Purity:97%Molecular weight:303.68Clofarabine - Bio-X ™
CAS:This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C10H11ClFN5O3Purity:Min. 95%Color and Shape:PowderMolecular weight:303.68 g/molClofarabine
CAS:Clofarabine is FDA-approved for treating relapsed or refractory acute lymphoblastic leukaemia (ALL) in children after at least two other types of treatment have failedFormula:C10H11ClFN5O3Purity:Min. 98 Area-%Color and Shape:White Off-White PowderMolecular weight:303.68 g/mol
