2'-Deoxyuridine

CAS: 951-78-0

Ref. 3D-ND06282

Product Information

• Name: 2'-Deoxyuridine
• Synonyms: 2'-Deoxy-D-uridine, 1-(2-Deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)uracil, 1-(2-Deoxy-β-D-erythro-pentofuranosyl)uracil, 1-(2-deoxy-alpha-L-erythro-pentofuranosyl)pyrimidine-2,4(1H,3H)-dione, 1-(2-deoxy-beta-L-erythro-pentofuranosyl)pyrimidine-2,4(1H,3H)-dione, 1-(2-deoxypentofuranosyl)pyrimidine-2,4(1H,3H)-dione, 1-[(3xi)-2-deoxy-beta-D-glycero-pentofuranosyl]pyrimidine-2,4(1H,3H)-dione, 2'-Desoxiuridina, 2'-Desoxyuridin, 2'-Desoxyuridine, 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)-, 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-, 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-β-D-erythro-pentofuranosyl)-, 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-β-D-ribofuranosyl)-, Deoxyribose uracil, Deoxyuridine, Nsc 23615, Uracil deoxyriboside, Uridine, 2'-deoxy-
• CAS: 951-78-0

Description

2'-Deoxyuridine (2'-dU) is an intermediate in the synthesis of thymidylate, which is a precursor for DNA synthesis. It can be prepared through high-performance liquid chromatography. 2'-dU has been shown to inhibit the enzymatic activity of enzymes responsible for synthesizing uridine and thymidylate, leading to neuronal death. 2'-dU has also been shown to have a protective effect against mitochondrial dysfunction induced by hydrogen fluoride. It is also known to bind with toll-like receptor 4 (TLR4), which is involved in inflammatory responses. 2'-dU has been used as a fluorescence probe for nucleic acids and as a polymerase chain reaction (PCR) substrate.

• Brand: Biosynth

Chemical properties

• Molecular weight: 228.21 g/mol
• Formula: C₉H₁₂N₂O₅
• Purity: Min. 98 Area-%
• Color/Form: White Powder
• InChI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6-,8-/m1/s1
• InChI key: InChIKey=MXHRCPNRJAMMIM-ATRFCDNQSA-N
• SMILES: O=c1ccn([C@H]2C[C@@H](O)[C@@H](CO)O2)c(=O)[nH]1