Product Information
- 5-Trifluoromethyldeoxycytidine
- 2'-Deoxy-5-(Trifluoromethyl)Cytidine
- 5-(Trifluoromethyl)-2-deoxycytidine
- 5-(Trifluoromethyl)-2'-Deoxycytidine
2'-Deoxy-5-(trifluoromethyl)cytidine is a synthetic nucleoside analogue that inhibits the cytidine deaminase enzyme. It is used in the treatment of some types of leukemia and other cancers. The compound, which has a trifluoromethyl group on the 2' position, binds to the active site of cytidine deaminase and prevents it from functioning. This leads to an accumulation of thymidylate, which is required for DNA synthesis. The tumor tissue also contains high concentrations of this drug and its metabolites, making it more effective against cancer cells than normal cells. 2'-Deoxy-5-(trifluoromethyl)cytidine has been shown to inhibit anabolism in tumor tissue in the presence of high concentrations of phosphorylases, which are enzymes that catalyze reactions that break down carbohydrates and proteins into smaller molecules such as glucose or amino acids.
Chemical properties
Technical inquiry about: 3D-NT11494 2'-Deoxy-5-(trifluoromethyl)cytidine
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