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Product Information
- Thieno[2,3-D]Pyrimidin-4-Ylamine
- Thieno[2,3-d]pyrimidine, 4-amino-
4-Aminothieno[2,3-d]pyrimidine is a potent inhibitor of the P-glycoprotein multidrug transporter. It has been shown to inhibit chloride transport in the kidney and gastrointestinal tract. 4-Aminothieno[2,3-d]pyrimidine also inhibits the function of amine oxidase, which is involved in the metabolism of endogenous compounds such as catecholamines and serotonin. This drug may also be effective against cancer cells. The mechanism of action for this drug is not well understood but it has been shown to have an effect on DNA replication and repair by inhibiting phosphorous acid and formamidines. 4-Aminothieno[2,3-d]pyrimidine can produce crosslinking between DNA strands that leads to chain termination or intramolecular hydrogen transfer with formamidines. This process produces formaldehyde, which can react with other molecules to produce crosslinks between
Chemical properties
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