Endothelin-3 (Human)

CAS: 117399-93-6

Ref. 3D-PED-4199-V

Product Information

• Name: Endothelin-3 (Human)
• Synonyms: Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp, Endothelin-3,Human, H-Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp-Oh, Endothelin-3 (Human, Mouse, Rabbit, Rat), Endothelin-3 (Human) (Porcine, Rat, Rabbit), Endothelin-3 (Human, Rat, Pig), Endothelin-3 (Human, Rat, Porcine, Rabbit)

Description

Endothelin-3 (ET-3) is a protein that belongs to the large family of endothelin peptides which activate the G-protein coupled receptors ETA and ETB. However ET-3 has lower affinity for the ETA receptors compared to Endothelin-1 (ET-1) and Endothelin-2 (ET-2), whereas all three endothelins have similar affinity for ETB receptors. As ETB receptors make up around 90% of the endothelin receptors found in the cerebral cortex in humans, ET-3 can be nicknamed the ‘brain endothelin’. Also through ET-3’s activation of ETB receptors, ET-3 is involved in the development of the enteric nervous system which controls within the gut, blood flow, secretion and intestinal motility. This product has disulfide bonds between Cys1-Cys and Cys3-Cys11, is sourced from Porcine, Rat and Rabbit and is available as a 0.5mg vial

• Brand: Biosynth

Chemical properties

• Molecular weight: 2,643 g/mol
• Formula: C₁₂₁H₁₆₈N₂₆O₃₃S₄
• Purity: Min. 95%