JW 67

CAS: 442644-28-2

Ref. 3D-SSA64428

Product Information

• Name: JW 67
• Brand: Biosynth
• Description: JW 67 is a small molecule inhibitor of the protein β-catenin. It has been shown to inhibit the growth of cancer cells and to reduce inflammation by inhibiting the production of inflammatory cytokines such as TNF-α and IL-6. JW 67 binds to the protein β-catenin, preventing it from binding to its cellular targets and thereby causing a decrease in cell proliferation. The compound also blocks the formation of new blood vessels that are characteristic of choroidal neovascularization in patients with age-related macular degeneration. This compound is not active against other proteins that share structural similarities with β-catenin, such as Axin2, Notch1, or c-Myc.JW 67 has been shown to be effective in treating atrial fibrillation by blocking the action of TGF-β1 on cardiac fibroblasts and cardiomyocytes, which leads to reduced fibrosis and increased contractility.

Chemical properties

• Molecular weight: 394.38 g/mol
• Formula: C₂₁H₁₈N₂O₆
• Purity: Min. 95%