Product Information
JW 67 is a small molecule inhibitor of the protein β-catenin. It has been shown to inhibit the growth of cancer cells and to reduce inflammation by inhibiting the production of inflammatory cytokines such as TNF-α and IL-6. JW 67 binds to the protein β-catenin, preventing it from binding to its cellular targets and thereby causing a decrease in cell proliferation. The compound also blocks the formation of new blood vessels that are characteristic of choroidal neovascularization in patients with age-related macular degeneration. This compound is not active against other proteins that share structural similarities with β-catenin, such as Axin2, Notch1, or c-Myc.
JW 67 has been shown to be effective in treating atrial fibrillation by blocking the action of TGF-β1 on cardiac fibroblasts and cardiomyocytes, which leads to reduced fibrosis and increased contractility.
Chemical properties
Technical inquiry about: 3D-SSA64428 JW 67
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