Polyinosinic-polycytidylic acid sodium salt

CAS: 42424-50-0

Ref. 3D-TP36521

Product Information

• Name: Polyinosinic-polycytidylic acid sodium salt
• Brand: Biosynth
• Description: Polyinosinic acid-polycytidylic acid (Poly I:C), an agonist of TLR3 toll-like receptors, is a synthetic double-stranded RNA analog, consisting of polyinosinic acid (poly I) paired with polycytidylic acid (poly C), forming a stable duplex structure. PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations. Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes. We can supply PolyI:C to all stages of your project - from R&D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products.For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'

Chemical properties

• Formula: (C₁₀H₁₃N₄O₈P)x•(C₉H₁₄N₃O₈P)x•Nax
• Color/Form: White Powder