E6446 (dihydrochloride)

CAS: 1345675-25-3

Ref. 3D-VDC67525

Product Information

• Name: E6446 (dihydrochloride)
• Brand: Biosynth
• Description: E6446 (dihydrochloride) is a small molecule compound that acts as a selective inhibitor of the mitotic kinesin Eg5, also known as KIF11. This compound is synthetically derived and is typically utilized in laboratory research. Its mode of action involves binding to the motor domain of Eg5, thereby inhibiting its ATPase activity, which is crucial for the Eg5-driven separation of spindle poles during cell mitosis. By selectively targeting Eg5, E6446 effectively disrupts mitotic spindle formation, leading to cell cycle arrest and apoptosis in rapidly dividing cells.These characteristics make E6446 an important tool in scientific research, particularly in the study of cancer cells and the development of anticancer therapies. Its ability to halt cell division without affecting other kinesins provides researchers with a precise method to investigate the role of mitotic kinesins in cell cycle progression and to screen for potential therapeutic compounds.

Chemical properties

• Molecular weight: 522.51 g/mol
• Formula: C₂₇H₃₇Cl₂N₃O₃
• Purity: Min. 95%