Product Information
KU 59403 is a radiosensitizing agent that belongs to the class of platinum-based chemotherapy. It has been shown to inhibit tumor growth in animal models. KU 59403 binds to and inhibits telomerase activity, which is necessary for cellular transformation. KU 59403 also sensitizes tumor cells to platinum-based chemotherapy drugs by inhibiting DNA repair mechanisms and phosphatases. The mechanism of action for KU 59403 involves dephosphorylation of histone H2AX, which leads to cell death in cancer cells. KU 59403 has been evaluated for clinical development as a radiosensitizer for prostate cancer treatment.
Chemical properties
Technical inquiry about: 3D-VIB93230 KU 59403
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