GSK343

CAS: 1346704-33-3

Ref. 3D-WDC70433

Product Information

• Name: GSK343
• Synonyms: 1-(1-Methylethyl)-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinyl)methyl]-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide, 1H-Indazole-4-carboxamide, N-[(1,2-dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-, Gsk 343, N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide

Description

GSK343 is a compound that inhibits the activity of histone methyltransferases. It is used in the treatment of cancer and has been shown to inhibit the growth of Hl-60 cells and 3T3-L1 preadipocytes. GSK343 also inhibits the proliferation of epithelial mesenchymal cells, which may be due to its ability to induce cell cycle arrest at G2/M phase. The inhibition of cancer cell proliferation by GSK343 has been linked to increased levels of the protein p27, which binds to cyclin D and prevents its association with CDK4 or CDK6. This results in reduced levels of cyclin E, Rb phosphorylation, and subsequent release from Rb inhibition. This leads to an increase in S phase followed by apoptosis. In addition, GSK343 has been shown to inhibit polymerase chain reaction (PCR) amplification of DNA by binding to double stranded DNA.

• Brand: Biosynth

Chemical properties

• Molecular weight: 541.7 g/mol
• Formula: C₃₁H₃₉N₇O₂
• Purity: Min. 95%