Product Information
Desmethylene tadalafil is a metabolite of tadalafil, which is a phosphodiesterase type-5 inhibitor. It is the desalkyl metabolite of tadalafil and is formed by human cytochrome P450 enzymes. It is also an inhibitor of phosphodiesterase type-5 (PDE5), which has been shown to be responsible for the degradation of cyclic guanosine monophosphate (cGMP) in smooth muscle cells. This inhibition leads to vasodilation, increased blood flow, and improved erectile function in humans. Desmethylene tadalafil has a half-life of approximately 16 hours, which is longer than that of sildenafil (approximately 4 hours). The binding properties of desmethylene tadalafil are similar to those of sildenafil, with the exception that it binds with lower affinity to PDE6 isoforms.
Chemical properties
Technical inquiry about: 3D-WGA48903 Desmethylene tadalafil
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