L 454560
CAS: 346629-30-9
Ref. 3D-WNA62930
| 1mg | To inquire | ||
| 5mg | To inquire | ||
| 10mg | To inquire | ||
| 25mg | To inquire | ||
| 50mg | To inquire |
Product Information
L 454560 is a ligand that binds to the phosphodiesterases PDE2B, PDE3A, and PDE5A. It is under investigation for the treatment of cognitive dysfunction associated with cardiovascular diseases. L 454560 has been shown to be effective in improving memory retention in preclinical models. In addition, it inhibits platelet aggregation in vitro and improves blood flow in vivo.
L 454560 has been shown to have a pharmacokinetic profile that is linear and dose proportional, with detectable levels at low doses (1-10 mg/kg). There are no significant drug-drug interactions observed between L 454560 and other drugs. The drug target for L 454560 is the phosphodiesterase enzyme family which regulates biochemical reactions involved in cognition and cardiovascular function.
Ligands such as L 454560 can be developed into potential drugs by targeting specific enzymes or proteins involved in disease pathology via inhibition or activation of these enzymes
Chemical properties
Technical inquiry about: 3D-WNA62930 L 454560
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