PRI-724
CAS: 1422253-38-0
Ref. 3D-XGC25338
| 10mg | 232.00 € | ||
| 25mg | 436.00 € | ||
| 50mg | 621.00 € | ||
| 100mg | 986.00 € | ||
| 250mg | 1,739.00 € |
Product Information
PRI-724 is a cell factor inhibitor that inhibits the growth of cells by binding to the CDK2 and CDK4 proteins. PRI-724 has significant cytotoxicity against a number of human carcinoma cell lines and has been shown to inhibit the activity index of epidermal growth factor. PRI-724 also reduces the expression of bcr-abl kinase, which plays a key role in chemoresistance, and polymerase chain reactions. It is thought that PRI-724 may act by blocking the binding between these two proteins and preventing transcriptional activation. The drug also blocks JAK2 V617F, which is associated with myeloproliferative diseases such as chronic myelogenous leukemia (CML).
Chemical properties
Technical inquiry about: 3D-XGC25338 PRI-724
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