Product Information
Ubch5C-in-1 is a small molecule inhibitor that targets the NF-κB signaling pathway. It is a covalent inhibitor of IKK (inhibitor of kappa B kinase). Ubch5C-in-1 has shown to be effective in inhibiting NF-κB activation and inflammatory cytokines such as TNF (tumor necrosis factor) and IL (interleukins) in different assays. It also inhibits the production of IL6, IL8, and MMP3, which are important mediators of inflammation. The mechanism of action of Ubch5C-in-1 is through covalent adduct formation with the active site of the enzyme IKK. This binding prevents phosphorylation on serine residues by IKK, blocking downstream signaling pathways that lead to inflammation. Ubch5C-in-1 has been found to be specific for NF-κB and does not inhibit other protein kinases
Chemical properties
Technical inquiry about: 3D-YJD48072 Ubch5C-in-1
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