Wedelolactone

CAS: 524-12-9

Ref. BP-BP1451

Product Information

• Name: Wedelolactone
• Synonyms: 5,11,12-Trihydroxy-7-methoxycoumestan, 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one, 1,8,9-Trihydroxy-3-methoxy-[1]benzofuro[3,2-c]chromen-6-one, 1,8,9-trihydroxy-3-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one, 6H-Benzofuro[3,2-c][1]benzopyran-6-one, 1,8,9-trihydroxy-3-methoxy-, 7-Methoxy-5,11,12-Trihydroxycoumestan

Description

​Wedelolactone is a potent Î2-arrestin-biased G protein-coupled receptor-35 (GPR35) agonist, GPR35 has been shown to be a target of the asthma drugs cromolyn disodium and nedocromil sodium. Wedelolactone has anti-inflammatory, growth inhibitory, anti-cancer, anti-fibrotic, and pro-apoptotic effects. Wedelolactone stimulates ER genomic and non-genomic signalling pathways; it can significantly inhibit the activation of LX-2 cells, the underlying mechanisms of which included inducing Bcl-2 family involved apoptosis, up-regulating phosphorylated status of ERK and JNK expressions, and inhibiting NF-κB mediated activity.

• Brand: Biopurify

Chemical properties

• Molecular weight: 314.249
• Formula: C₁₆H₁₀O₇
• Purity: 95%~99%
• InChI: InChI=1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3
• InChI key: InChIKey=XQDCKJKKMFWXGB-UHFFFAOYSA-N
• SMILES: COc1cc(O)c2c(c1)oc(=O)c1c3cc(O)c(O)cc3oc21