CAS 524-12-9

Wedelolactone

Description:

Wedelolactone is a naturally occurring compound classified as a coumarin derivative, primarily extracted from various plants, including those in the genus *Wedelia*. It is characterized by its aromatic structure, which includes a lactone functional group, contributing to its distinctive chemical properties. The compound exhibits a range of biological activities, including anti-inflammatory, antioxidant, and potential anticancer effects, making it of interest in pharmacological research. Wedelolactone is soluble in organic solvents but has limited solubility in water, which influences its bioavailability and application in medicinal chemistry. Its molecular formula is C10H10O3, and it has a relatively low molecular weight. The compound's structure allows it to interact with various biological targets, and ongoing studies continue to explore its therapeutic potential. Additionally, due to its natural origin, wedelolactone is often investigated for its role in traditional medicine and its possible applications in modern therapeutic contexts.

Formula: C₁₆H₁₀O₇

InChI: InChI=1/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3

InChI key: InChIKey=XQDCKJKKMFWXGB-UHFFFAOYSA-N

SMILES: O=C1C2=C(C=3C(O1)=CC(OC)=CC3O)OC=4C2=CC(O)=C(O)C4

Synonyms:

• 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one
• 1,8,9-Trihydroxy-3-methoxy-[1]benzofuro[3,2-c]chromen-6-one
• 1,8,9-trihydroxy-3-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one
• 6H-Benzofuro[3,2-c][1]benzopyran-6-one, 1,8,9-trihydroxy-3-methoxy-
• 7-Methoxy-5,11,12-Trihydroxycoumestan
• Wedelolactone
• Wedelia lactone
• Wedelolactone, ≥98%(HPLC)
• 5,11,12-Trihydroxy-7-MethoxycouMestan
• IKK Inhibitor II, Wedelolactone
• Wedelolactone CRS
• Wedelolactone, 98%, from Wedelia chinensis (Osbeck.) Merr.
• 1,8,9-trihydroxy-3-Methoxy-6H-benzofuro[3,2-c]chroMen-6-one

Wedelolactone

CAS: 524-12-9

Wedelolactone analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formula: C₁₆H₁₀O₇

Purity: (HPLC) ≥99%

Color and Shape: Powder

Molecular weight: 314.25

Ref: 11-0555S

WEDELOLACTONE CRS

CAS: 524-12-9

WEDELOLACTONE CRS

Formula: C₁₆H₁₀O₇

Molecular weight: 314.2464

Ref: 41-Y0001599

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one

CAS: 524-12-9

Formula: C₁₆H₁₀O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 314.2464

Ref: IN-DA00DA52

Wedelolactone

CAS: 524-12-9

Wedelolactone

Formula: C₁₆H₁₀O₇

Purity: 98%

Molecular weight: 314.25

Ref: 54-OR1022962

Wedelolactone

CAS: 524-12-9

Wedelolactone

Formula: C₁₆H₁₀O₇

Purity: ≥98%

Molecular weight: 314.25

Ref: 54-BUP07197

Wedelolactone

CAS: 524-12-9

​Wedelolactone is a potent Î2-arrestin-biased G protein-coupled receptor-35 (GPR35) agonist, GPR35 has been shown to be a target of the asthma drugs cromolyn disodium and nedocromil sodium. Wedelolactone has anti-inflammatory, growth inhibitory, anti-cancer, anti-fibrotic, and pro-apoptotic effects. Wedelolactone stimulates ER genomic and non-genomic signalling pathways; it can significantly inhibit the activation of LX-2 cells, the underlying mechanisms of which included inducing Bcl-2 family involved apoptosis, up-regulating phosphorylated status of ERK and JNK expressions, and inhibiting NF-κB mediated activity.

Formula: C₁₆H₁₀O₇

Purity: 95%~99%

Molecular weight: 314.249

Ref: BP-BP1451

Wedelolactone (Standard)

CAS: 524-12-9

Wedelolactone (Standard) is a reference standard for research and analysis in studies involving Wedelolactone. Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.

Formula: C₁₆H₁₀O₇

Color and Shape: Solid

Molecular weight: 314.25

Ref: TM-TMSM-2598

Wedelolactone

CAS: 524-12-9

Formula: C₁₆H₁₀O₇

Purity: >98.0%(HPLC)

Color and Shape: White to Dark green powder to crystal

Molecular weight: 314.25

Ref: 3B-W0015

Wedelolactone

CAS: 524-12-9

Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.

Formula: C₁₆H₁₀O₇

Purity: 98.07% - 99.87%

Color and Shape: Solid

Molecular weight: 314.25

Ref: TM-T3384

Wedelolactone

CAS: 524-12-9

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one

Formula: C₁₆H₁₀O₇

Purity: 98%

Molecular weight: 314.25

Ref: IN-DG298251

Wedelolactone

CAS: 524-12-9

Formula: C₁₆H₁₀O₇

Molecular weight: 314.25

Ref: 7W-GL6617

Wedelolactone

CAS: 524-12-9

Lactone

Formula: C₁₆H₁₀O₇

Purity: ≥ 90.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 314.25

Ref: 5G-89823

Wedelolactone

CAS: 524-12-9

Wedelolactone is a naturally occurring bioactive compound, classified as a coumestan, which is derived from the plant Eclipta alba, commonly referred to as false daisy. This polyphenolic compound exerts its effects through various modes of action, including inhibition of 5-lipoxygenase and modulation of NF-κB signaling pathways. The inhibition of these pathways suggests its potential role in the regulation of inflammation and cell proliferation.

Formula: C₁₆H₁₀O₇

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 314.25 g/mol

Ref: 3D-FW73945

Wedelolactone

CAS: 524-12-9

Ref: BE-RMT13870

Wedelolactone

CAS: 524-12-9

Ref: BE-促RMT13870

Wedelolactone

CAS: 524-12-9

M06041 - Wedelolactone

Formula: C₁₆H₁₀O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 314.249

Ref: 10-M06041

Wedelolactone

Controlled Product

CAS: 524-12-9

Formula: C₁₆H₁₀O₇

Color and Shape: Neat

Molecular weight: 314.25

Ref: TR-W980008