Desonide

CAS: 638-94-8

Ref. TM-T1168

Product Information

• Name: Desonide
• Synonyms: Tridesilon, Locapred, Prednacinolone, (11β,16α)-11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione, 11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione 16,17-acetonide, 11β,21-Dihydroxy-16α,17α-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione, 16α,17α-(Isopropylidenedioxy)prednisolone, 16α-Hydroxyprednisolone 16,17-acetonide, 16α-Hydroxyprednisolone 16α,17α-acetonide, 16α-Hydroxyprednisolone acetonide, 2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregna-1,4-diene-3,20-dione deriv., Apolar, Budesonide acetonide, D 2083, Desonid, Desonida, Desowen, Locapred, Prednacinolone, Prednacinolone acetonide, Prednisolone acetonide, Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11β,16α)-, Pregna-1,4-diene-3,20-dione, 11β,16α,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone, Prenacid, Sterax, Steroderm, Topifug, Tridesilon, Tridesonit
• CAS: 638-94-8

Description

Desonide (Prednacinolone) is a synthetic glucocorticosteroid for topical use, with anti-inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and the ligand-receptor complex is translocated as a homodimer into the nucleus, where transcription activation via glucocorticoid response elements within glucocorticoid-responsive genes occur. This agent induces transcription of genes coding for anti-inflammatory proteins, including lipocortin-1, interleukin-10, interleukin-1 receptor antagonist and neutral endopeptidase. Increased synthesis of lipocortin-1 has an inhibitory effect on phospholipase A2, which in turn inhibits the release of arachidonic acid, thereby controlling the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

• Brand: Targetmol

Chemical properties

• Molecular weight: 416.51
• Formula: C₂₄H₃₂O₆
• Purity: 99.5%
• Color/Form: Solid