CAS 638-94-8
:Desonide
Description:
Desonide is a synthetic corticosteroid primarily used for its anti-inflammatory and immunosuppressive properties in dermatological applications. It is characterized by its relatively low potency compared to other corticosteroids, making it suitable for treating mild to moderate skin conditions such as eczema, dermatitis, and psoriasis. Desonide is typically formulated in topical preparations, including creams, ointments, and lotions, allowing for localized treatment with minimal systemic absorption. The chemical structure of desonide includes a steroid nucleus, which is essential for its biological activity, and it exhibits a favorable safety profile, particularly for use in sensitive areas of the skin. Its mechanism of action involves the inhibition of inflammatory mediators, thereby reducing redness, swelling, and itching. As with all corticosteroids, prolonged use may lead to potential side effects, including skin thinning and tolerance, so it is recommended to use desonide under the guidance of a healthcare professional. Overall, desonide serves as an effective option for managing various inflammatory skin disorders while minimizing the risk of adverse effects associated with more potent corticosteroids.
Formula:C24H32O6
InChI:InChI=1S/C24H32O6/c1-21(2)29-19-10-16-15-6-5-13-9-14(26)7-8-22(13,3)20(15)17(27)11-23(16,4)24(19,30-21)18(28)12-25/h7-9,15-17,19-20,25,27H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,20+,22-,23-,24+/m0/s1
InChI key:InChIKey=WBGKWQHBNHJJPZ-LECWWXJVSA-N
SMILES:C(CO)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(OC(C)(C)O2)[H])([C@]4([C@]([C@@H](O)C3)([C@]5(C)C(CC4)=CC(=O)C=C5)[H])[H])[H]
Synonyms:- (11β,16α)-11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
- 11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione 16,17-acetonide
- 11β,21-Dihydroxy-16α,17α-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione
- 16α,17α-(Isopropylidenedioxy)prednisolone
- 16α-Hydroxyprednisolone 16,17-acetonide
- 16α-Hydroxyprednisolone 16α,17α-acetonide
- 16α-Hydroxyprednisolone acetonide
- 2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregna-1,4-diene-3,20-dione deriv.
- Apolar
- Budesonide acetonide
- D 2083
- Desonid
- Desonida
- Desowen
- Locapred
- Prednacinolone
- Prednacinolone acetonide
- Prednisolone acetonide
- Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11β,16α)-
- Pregna-1,4-diene-3,20-dione, 11β,16α,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
- Prenacid
- Sterax
- Steroderm
- Topifug
- Tridesilon
- See more synonyms
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Desonide
CAS:Formula:C24H32O6Purity:>98.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:416.51Desonide
CAS:Adrenal cortical hormones and their derivatives nesoiFormula:C24H32O6Color and Shape:White Off-White PowderMolecular weight:416.21989Desonide
CAS:Desonide is a synthetic topical steroid that reduces inflammation by inhibiting key inflammatory mediators.Formula:C24H32O6Purity:99.50% - 99.74%Color and Shape:SolidMolecular weight:416.5073Desonide (Budesonide EP Impurity F)
CAS:Formula:C24H32O6Color and Shape:White To Off-White SolidMolecular weight:416.5116alpha,17-[1-Methylethylidenebis(oxy)]-11beta,21-dihydroxypregna-1,4-diene-3,20-dione (Desonide)
CAS:Formula:C24H32O6Color and Shape:NeatMolecular weight:416.51(11β,16α)-11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
CAS:Formula:C24H32O6Purity:98%Color and Shape:SolidMolecular weight:416.5073Desonide-13C3
CAS:Controlled ProductApplications Anti-inflammatory.
References Phillips, et al.: Toxicol. Appl. Pharmacol., 20, 522 (1971), Sanen, F.J., et al.: Int. J. Clin. Pharmacol. Biopharm., 12, 174 (1975), Tarayre, J.P., et al.: Pharmacol., 19, 323 (1979).Formula:C2113C3H32O6Color and Shape:NeatMolecular weight:419.49Desonide
CAS:Controlled ProductImpurity Budesonide EP Impurity F
Applications Desonide(Budesonide EP Impurity F) is an impurity of Budesonide (B689490), an anti-inflammatory.
References Phillips, et al.: Toxicol. Appl. Pharmacol., 20, 522 (1971), Sanen, F.J., et al.: Int. J. Clin. Pharmacol. Biopharm., 12, 174 (1975), Tarayre, J.P., et al.: Pharmacol., 19, 323 (1979).Formula:C24H32O6Color and Shape:NeatMolecular weight:416.51Desonide
CAS:Desonide is a synthetic, low-potency corticosteroid with antiinflammatory activity. It is chemically stable and has only minimal potential for skin irritation. The pharmacokinetics of desonide have been studied in humans and rats. Desonide is metabolized to betamethasone, its active form, which binds to glucocorticoid receptors in the nucleus of cells. This binding inhibits the transcription of genes that regulate inflammatory responses, leading to relief from symptoms such as redness, swelling, and itching. Desonide has shown efficacy in the treatment of alopecia areata (hair loss) with topical application.Formula:C24H32O6Purity:Min. 95%Color and Shape:White PowderMolecular weight:416.51 g/mol
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