Propylthiouracil

CAS: 51-52-5

Ref. TM-T1309

Product Information

• Name: Propylthiouracil
• Synonyms: 6-Propyl-2-thiouracil, NSC 70461, Pseudocapsaicin, 6-n-Propylthiouracil, NSC 6498, 1-propyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one, 2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone, 2-Mercapto-4-hydroxy-6-n-propylpyrimidine, 2-Mercapto-4-hydroxy-6-propylpyrimidine, 2-Mercapto-6-propylpyrimidin-4-ol, 2-Thio-4-oxo-6-propyl-1,3-pyrimidine, 2-Thio-6-propyl-1,3-pyrimidin-4-one, 4(1H)-Pyrimidinone, 2,3-dihydro-6-propyl-2-thioxo-, 6-Propyl-2-Thiouracyle, 6-Propyl-2-thio-2,4(1H,3H)pyrimidinedione, 6-Propyl-2-thiouracil, 6-Propyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one, 6-Propylthiouracil, 6-n-Propyl-2-thiouracil, 6-n-Propylthiouracil, Nsc 6498, Nsc 70461, PTU, PTU (thyreostatic), Procasil, Propacil, Propiltiouracilo, Propycil, Propyl-Thiorist, Propyl-Thyracil, Propylthiorit, Propylthiouracile, Prothiucil, Prothiurone, Prothycil, Prothyran, Protiural, Thiuragyl, Thyreostat II, Uracil, 4-Propyl-2-Thio-, Uracil, 6-propyl-2-thio-
• CAS: 51-52-5

Description

Propylthiouracil is a thiourea derivative with an antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with peroxidase or a peroxidase-mediated complex reaction, thereby inhibiting synthesis of thyroid hormones tri-iodothyronine (T3) and thyroxine (T4). In addition, this agent inhibits the Type I 5'-deiodinase (D1), an enzyme involved in the peripheral conversion of thyroxine to tri-iodothyronine. This results in decreased plasma triiodothyronine concentrations and decreased entrance of thyroxine into cells thereby reducing thyroid hormone activity.

Chemical properties

• Molecular weight: 170.23
• Formula: C₇H₁₀N₂OS
• Purity: 99.94%
• Color/Form: White Crystalline Powder Of Starch-Like Appearance To Eye And To Touch Saturated Solution Is Neutral Or Slightly Acid To Litmus (Ntp 1992)