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CAS 51-52-5

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Propylthiouracil

Description:
Propylthiouracil (PTU) is an antithyroid medication primarily used to manage hyperthyroidism, particularly in conditions like Graves' disease. It functions by inhibiting the enzyme thyroid peroxidase, which is crucial for the synthesis of thyroid hormones, thereby reducing their production. PTU is a white to off-white crystalline powder that is slightly soluble in water and more soluble in organic solvents. Its molecular formula is C7H10N2OS, and it has a molecular weight of approximately 170.24 g/mol. The compound is known for its ability to cross the placenta and is sometimes used in pregnant women to treat hyperthyroidism, although caution is advised due to potential side effects. Common side effects include rash, liver toxicity, and agranulocytosis, necessitating regular monitoring of blood counts during treatment. Propylthiouracil is typically administered orally and is available in tablet form. Its pharmacokinetics involve rapid absorption and a relatively short half-life, requiring multiple daily doses for effective management of thyroid hormone levels.
Formula:C7H10N2OS
InChI:InChI=1/C7H10N2OS/c1-2-4-9-5-3-6(10)8-7(9)11/h3,5H,2,4H2,1H3,(H,8,10,11)
InChI key:InChIKey=KNAHARQHSZJURB-UHFFFAOYSA-N
SMILES:C(CC)C1=CC(=O)NC(=S)N1
Synonyms:
  • 1-propyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
  • 2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone
  • 2-Mercapto-4-hydroxy-6-n-propylpyrimidine
  • 2-Mercapto-4-hydroxy-6-propylpyrimidine
  • 2-Mercapto-6-propylpyrimidin-4-ol
  • 2-Thio-4-oxo-6-propyl-1,3-pyrimidine
  • 2-Thio-6-propyl-1,3-pyrimidin-4-one
  • 4(1H)-Pyrimidinone, 2,3-dihydro-6-propyl-2-thioxo-
  • 6-Propyl-2-Thiouracyle
  • 6-Propyl-2-thio-2,4(1H,3H)pyrimidinedione
  • See more synonyms
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Found 14 products.