MEK/RAF-IN-1
Ref. TM-T200267
Product Information
Name:MEK/RAF-IN-1
Brand:Targetmol
Description:MEK/RAF-IN-1 (Compound 16b) serves as an inhibitor targeting both MEK and RAF, demonstrating potent efficacy with IC 50 values reported at 28 nM for MEK1, and 3 nM for both BRAF and BRAFV600E. This compound exhibits significant antitumor capabilities, effectively curbing cell proliferation in vitro in MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Furthermore, MEK/RAF-IN-1 significantly restricts tumor growth in xenograft mouse models employed in the study of colorectal cancer.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:618.63
Formula:C28H29F3N6O5S
Color/Form:Solid
Technical inquiry about: MEK/RAF-IN-1
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