TH023
Ref. TM-T201758
Product Information
Name:TH023
Brand:Targetmol
Description:TH023 is an inhibitor of the TLR4 signaling pathway, specifically targeting the formation of TLR4 homodimers. In HEK-Blue hTLR4 cells, TH023 suppresses the secretion of embryonic alkaline phosphatase with an IC50 of 0.354 μM and inhibits NO expression in RAW264.7 cells, with an IC50 of 1.61 μM. Additionally, TH023 inhibits the activation of NF-κB and reduces the nuclear translocation of NF-κB p65. The compound demonstrates anti-inflammatory effects in a mouse model of LPS-induced acute sepsis and improves lung injury in mice.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:430.88
Formula:C22H21ClF2N4O
Color/Form:Solid
Technical inquiry about: TH023
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