SOS1-IN-17
Ref. TM-T203656
Product Information
Name:SOS1-IN-17
Brand:Targetmol
Description:SOS1-IN-17 (Compound 8d) is an orally active inhibitor targeting the SOS1-KRASG12C interaction, with an IC50 of 5.1 nM. It suppresses ERK phosphorylation in DLD-1 cells with an IC50 of 18 nM and demonstrates antiproliferative activity in KRASG12C-mutant Mia-Paca-2 cells, with an IC50 of 0.11 μM. In mouse models, SOS1-IN-17 shows antitumor efficacy against pancreatic cancer.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:541.61
Formula:C29H34F3N5O2
Color/Form:Solid
Technical inquiry about: SOS1-IN-17
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