Product Information
Name:KRAS inhibitor-27
Brand:Targetmol
Description:KRAS inhibitor-27 (Compound 15h) is a KRAS inhibitor that effectively targets KRAS G12D/G12V mutated cells (AsPC-1 and SW620) and wild-type KRAS cells (HT-29), with IC50 values of 378 nM, 0.6 nM, and 3230 nM, respectively. It reduces ERK phosphorylation, with IC50 values of 0.6 nM and 1 nM in AsPC-1 and SW620 cells, respectively, and decreases DUSP4 expression, thereby inhibiting the MAPK signaling pathway.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:657.106
Formula:C31H28ClF3N6O3S
Color/Form:Solid
Technical inquiry about: KRAS inhibitor-27
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