ICT10336
Ref. TM-T210166
10mg
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50mg
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Product Information
Name:ICT10336
Brand:Targetmol
Description:ICT10336 is a hypoxia-reactive prodrug of the ATR inhibitor AZD6738. It specifically activates under hypoxic conditions in vitro, selectively releasing AZD6738. This action inhibits ATR activation at the T1989 and S428 phosphorylation sites, consequently disrupting HIF1a-mediated adaptation of hypoxic cancer cells and inducing cell death in both 2D and 3D cancer models. ICT10336 is also a metabolic substrate of CYPOR activity.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:708.28021
Formula:C32H40N10O7S
Color/Form:Solid
Technical inquiry about: ICT10336
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