Product Information
Name:A2AR modulator-1
Brand:Targetmol
Description:A2AR modulator-1 (Compound 45) is a selective negative allosteric modulator of the adenosine A2a receptor (A2aR), with an IC50 value of 9 nM. It reduces the affinity of endogenous adenosine for the receptor and inhibits the activation of the cAMP signaling pathway. A2AR modulator-1 effectively restores pCREB phosphorylation in CD4+ T cells, reverses immunosuppression in the tumor microenvironment, and shows potential in inhibiting tumor growth and metastasis in a triple-negative breast cancer model.
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Chemical properties
Molecular weight:380.45
Formula:C23H20N6
Color/Form:Solid
Technical inquiry about: A2AR modulator-1
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