Product Information
Name:NLRP3-IN-81
Brand:Targetmol
Description:NLRP3-IN-81 (N102) is an inhibitor capable of crossing the blood-brain barrier, effectively countering NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 μM for Nigericin-induced pyroptosis. It significantly suppresses caspase-1 activation and IL-1β release that depend on NLRP3. Additionally, NLRP3-IN-81 disrupts the interaction between NLRP3 and the adaptor protein ASC, while inhibiting ASC oligomerization. This compound is applicable in research on pyroptosis-related diseases, such as inflammatory bowel disease and type 2 diabetes.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:372.36
Formula:C16H15F3N2O3S
Color/Form:Solid
Technical inquiry about: NLRP3-IN-81
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