ALK degrader 2
Ref. TM-T212332
10mg
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50mg
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Product Information
Name:ALK degrader 2
Brand:Targetmol
Description:ALK degrader 2 is an orally active ALK degrader that reduces EML4-ALK protein levels (DC50= 8 nM) and nucleophosmin (NPM)-ALK protein levels (DC50= 102 nM). It facilitates ALK degradation through the Hsp70 chaperone system and the ubiquitin-proteasome pathway. In H3122 cells, ALK degrader 2 causes significant cell cycle arrest at the S phase and induces apoptosis. Additionally, it demonstrates antitumor activity in mice with H3122 xenograft tumors. ALK degrader 2 is a useful compound in researching non-small cell lung cancer (NSCLC).
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Color/Form:Odour Solid
Technical inquiry about: ALK degrader 2
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