Product Information
Name:Naperiglipron
Synonyms:
- LY3549492
Brand:Targetmol
Description:Naperiglipron (LY3549492) (Example 2) is a glucagon-like peptide-1 receptor (GLP-1R) agonist with an EC50 of 1.14 nM for hGLP-1R. It markedly reduces blood glucose levels in GLP-1R gene knock-in mouse models. Additionally, Naperiglipron inhibits PDE10A1 enzyme activity (IC50: 7.43 μM) and exhibits weak hERG inhibitory activity. This compound is applicable in research on Type II diabetes mellitus (T2DM) and obesity.
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Chemical properties
Molecular weight:580.59
Formula:C33H26F2N4O4
Technical inquiry about: Naperiglipron
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